Work began at 6pm BST on Wednesday, the company said.
The harsh environment jack-up rig Maersk Highlander is drilling the first production well through a wellhead platform (WHP) jacket and well access deck, which were installed at the field this spring.
Continuous drilling activity is planned over the next five years.
(Catch our in-depth report on Culzean from June here.)
“This is an important milestone in ensuring that we can deliver Culzean on schedule, and with it 5% of UK gas demand in 2020/2021," said Gretchen Watkins, who is set to take over as chief executive of the operator in the coming weeks.
“It’s